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To analyze the characteristics of envelope protein (envelope, E) gene in dengue fever cases in Hubei Province from 2014 to 2023 and to trace the biological origin.
Serum samples of suspected dengue fever cases were collected, and nucleic acid detection and serum typing were carried out. Nucleic acid positive samples were amplified by RT-PCR and sequenced, and the gene sequences were obtained and analyzed by MEGA11.0 software.
A total of 78 dengue nucleic acid positive cases were detected in Hubei Province from 2014 to 2023, and the E gene sequence of dengue virus (DENV) was successfully obtained in 44 samples, including 39 cases of serum type Ⅰ (DENV-Ⅰ) and 5 cases of serum typeⅡ (DENV-Ⅱ). Evolutionary analysis showed that 37 cases of DENV-Ⅰ were of gene type Ⅰ (G Ⅰ), distributed in three different branches, mainly close to the epidemic strains of Southeast Asian countries such as Guangzhou, Singapore, Indonesia, Thailand, and Myanmar, 2 cases were of gene type Ⅴ (GⅤ) were close to the epidemic strains of Guangzhou and India, and 5 cases of DENV-Ⅱ were of mixed type (Cosmopolitan type).
There was multitype dengue virus infection in Hubei Province from 2014 to 2023. The main epidemic strain was GⅠ subtype of DENV-Ⅰ, which was closely related to Guangzhou, China, and Southeast Asian countries. It is suggested that Hubei Province strengthen the prevention and control of cross-provincial and cross-border transmission of dengue fever and guard against the occurrence of severe dengue and death cases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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