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To analyze the correlation between the age at menarche(AAM) and the incidence of hypertension.
Based on the baseline data of 1 499 women from a national key research and development program “Natural population cohort study of heavy air pollution in Sichuan basin” in Rongchang District, 4 townships were randomly selected in 2018. Questionnaire survey, physical examination, and blood biochemical tests were carried out among the people aged 30 to 79 who were registered in the selected townships. The correlation and sensitivity between AAM and hypertension were analyzed by logistic regression model and restricted cubic spline was drawn by software R4.1.1.
The AAM of 1 499 female subjects was 14.31±2.06 years old, and the prevalence rate of hypertension was 36.62%. The prevalence rates of hypertension of ≤ 12 years old, 13 years old, 14 years old, 15 years old, and ≥ 16 years old were 22.88%, 27.02%, 33.33%, 45.61%, and 52.63%, respectively, showing an upward trend (trend χ2=52.198, P<0.001). After adjusting the confounding factors, compared with the 14 years old group in the control group, ≤ 12 years old (OR=0.793, 95%CI: 0.684-0.918), 13 years old (OR=0.865, 95%CI: 0.468-0.935), 15 years old (OR=1.513, 95%CI: 1.117-2.050), and ≥ 16 years old (OR=1.801, 95%CI: 1.483-2.118) were associated with hypertension. The restriction cubic spline showed that there was a non-linear dose-response relationship between AAM and hypertension (P<0.001), and the later AAM was associated with the high risk of hypertension. Sensitivity analysis showed that the correlation between AAM and hypertension still existed in different birth cohorts and BMI groups.
The later AAM may increase the risk of hypertension in adults. Strengthening health education and improving behavior and lifestyle are beneficial to the prevention and treatment of hypertension in women.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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