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To investigate the association between obesity and non-alcoholic fatty liver disease (NAFLD) in the occupational population, and the mediating role played by hyperuricemia in the association, to provide reference for the prevention and intervention strategies of NAFLD in the occupational population.
Multistage cluster sampling was used to survey occupational population in Chongqing Municipality, Sichuan Province, and Guizhou Province to obtain social and demographic indicators, lifestyle and health status indicators, and to collect physical examination indicators from the survey respondents. The correlation between obesity and NAFLD was analyzed by Spearman’s rank correlation coefficient and multivariable adjusted Logistic regression. The mediating effect of hyperuricemia in the association between obesity and NAFLD was explored by mediating effect model.
A total of 15 029 study participants who met the inclusion criteria were enrolled, including 1 190 patients with NAFLD. The results of Logistic regression showed that, after adjusting for covariates such as age and gender, obesity increased the risk of NAFLD (OR=3.37, 95% CI: 2.78 to 4.09) and was associated with higher risk of NAFLD in those aged <45 years (OR=3.93, 95% CI: 3.12 to 4.94) and female subgroups (OR=3.65, 95% CI: 1.98 to 6.71) had greater effect values for the effect of obesity on NAFLD. The mediation analysis found that hyperuricemia mediated 11.72% of the effect between obesity and NAFLD, and in the subgroup analysis, the mediation effect of hyperuricemia was higher in the female subgroups (23.81%).
Obesity is strongly associated with the incident of NAFLD, with a greater effect in younger and female groups, and affects NAFLD through hyperuricemia. Strengthening the preventive education of obesity and hyperuricemia and advocating a healthy lifestyle may be effective in reducing NAFLD caused by obesity and hyperuricemia.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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