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To optimize the extraction process of total flavonoids from Allium mongolicum and investigate its in vitro hypoglycemic and hypolipidemic activities as well as preventive effects on high-fat diet-induced obesity in mice.
Single-factor experiments and Box-Behnken response surface methodology were employed to determine the optimal extraction conditions. In vitro experiments evaluated the inhibitory effects on pancreatic lipase and α-glucosidase activities. Male C57BL/6J mice were randomly divided into control, high-fat diet (HFD), and three treatment groups (0.75, 1.5, and 2.25 g/kg doses),with six mice per group. After 8 weeks of intervention, serum lipid profiles, liver enzymes, blood glucose, and histopathological changes were analyzed.
The optimal extraction conditions yielded 10.43 (±0.52) mg/g total flavonoids. The IC50 values for pancreatic lipase and α-glucosidase inhibition were 0.99 mg/ml and 5.17 mg/ml, respectively. Compared with HFD group, medium and high dose groups showed significant reductions in body weight, fat mass, serum TC, TG, LDL-C, ALT, AST, and blood glucose levels (P<0.05), along with improved hepatic and adipose tissue pathology.
The optimized extraction process effectively enhances flavonoid yield from Allium mongolicum, and the obtained flavonoids demonstrate potential in preventing high-fat diet-induced obesity by improving glucose and lipid metabolism disorders.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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