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Gut microbiome characteristics of Tibetan hyperuricemia patients in Lhasa based on metagenomic sequencing
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Wen-yi YUAN1, Qing-yu DOU2, Qing-quan KONG3, 4, NYIMA Qu-cuo5, DORJE Zhuo-ma6, Xing ZHAO1, Shu-juan YANG1, Pei-bin ZENG1, Nu-jia YOU1
Modern Preventive Medicine | 2025, 52(13) : 2450 - 2458
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Modern Preventive Medicine | 2025, 52(13): 2450-2458
• Experimental Technology and Applications •
Gut microbiome characteristics of Tibetan hyperuricemia patients in Lhasa based on metagenomic sequencing
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Wen-yi YUAN1, Qing-yu DOU2, Qing-quan KONG3, 4, NYIMA Qu-cuo5, DORJE Zhuo-ma6, Xing ZHAO1, Shu-juan YANG1, Pei-bin ZENG1, Nu-jia YOU1
Affiliations
  • West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2025-07-10 doi: 10.20043/j.cnki.MPM.202501024
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Objective

To investigate the compositional and functional differences in gut microbiota between Tibetan hyperuricemia patients and healthy controls in Lhasa.

Methods

From the Southwest China Natural Population Cohort, 108 Tibetan participants were enrolled and stratified into hyperuricemia and control groups based on serum uric acid levels. Fecal samples underwent metagenomic sequencing, with bioinformatics analyses comparing microbial composition and function. Spearman correlation and linear regression assessed phenotype-microbiome associations.

Results

Hyperuricemia patients showed significantly reduced α-diversity (W=938.000, P=0.046). Fusobacterium varium (LDA=4.315, P<0.001), Bifidobacterium pseudolongum (LDA=4.284, P=0.018), and Oscillibacter sp. PEA192 (LDA=4.259, P=0.050) were enriched in hyperuricemia, whereas Bacteroides uniformis (LDA=4.032, P<0.001), Phocaeicola dorei (LDA=3.750, P=0.028), and Bacteroides fragilis (LDA=3.945, P=0.005) predominated in controls. B. pseudolongum positively correlated with hyperuricemia (r=0.267, P=0.005), while B. uniformis showed negative association (r=-0.305, P=0.001).

Conclusion

Tibetan hyperuricemia patients exhibit gut dysbiosis characterized by reduced beneficial bacteria and increased pathogenic species, which may contribute to disease pathogenesis.

Tibetan  /  Hyperuricemia  /  Gut microbiota  /  Metagenomics
Wen-yi YUAN, Qing-yu DOU, Qing-quan KONG, NYIMA Qu-cuo, DORJE Zhuo-ma, Xing ZHAO, Shu-juan YANG, Pei-bin ZENG, Nu-jia YOU. Gut microbiome characteristics of Tibetan hyperuricemia patients in Lhasa based on metagenomic sequencing[J]. Modern Preventive Medicine, 2025 , 52 (13) : 2450 -2458 . DOI: 10.20043/j.cnki.MPM.202501024
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Year 2025 volume 52 Issue 13
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Article Info
doi: 10.20043/j.cnki.MPM.202501024
  • Receive Date：2025-01-02
  • Online Date：2026-03-19
  • Published：2025-07-10
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  • Received：2025-01-02
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    West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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