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Walnut-derived peptides ameliorate aluminum-induced cognitive impairment via miR-124-3p/STAT3-TGF-β1/Smad3 signaling pathway in rats
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Xiao-yu ZHANG1, Xiu-feng WANG3, Quan-yue WANG2, Bing-yi WANG2, Li LIN2, Jing ZHANG1, 2, Huan LI2
Modern Preventive Medicine | 2025, 52(13) : 2374 - 2378
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Modern Preventive Medicine | 2025, 52(13): 2374-2378
• Nutrition and Food Hygiene •
Walnut-derived peptides ameliorate aluminum-induced cognitive impairment via miR-124-3p/STAT3-TGF-β1/Smad3 signaling pathway in rats
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Xiao-yu ZHANG1, Xiu-feng WANG3, Quan-yue WANG2, Bing-yi WANG2, Li LIN2, Jing ZHANG1, 2, Huan LI2
Affiliations
  • School of Public Health and Health Management, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Published: 2025-07-10 doi: 10.20043/j.cnki.MPM.202502076
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Objective

To investigate the effects of walnut-derived peptides (WDP) on miR-124-3p, STAT3, TGF-β1, and Smad3 proteins in aluminum-induced cognitive impairment.

Methods

Forty male SD rats were divided into control (saline),aluminum model (20 μmol/kg aluminum maltolate, Al (mal)3), 45-day WDP treatment (Al (mal)3 + 800 mg/kg WDP from day 45), and 90-day WDP prevention (Al (mal)3 + 800 mg/kg WDP from day 1) groups (n=10 each). Cognitive function was assessed by Morris water maze. Hippocampal protein expressions (p-STAT3 Ser727, p-STAT3 Tyr705, TGF-β1, p-Smad3 Ser423/425) and miR-124-3p levels were measured.

Results

Aluminum exposure prolonged escape latency from day 2 (P<0.05), which was attenuated by WDP (P<0.05). Aluminum increased hippocampal p-STAT3, TGF-β1, and p-Smad3 expressions while decreasing miR-124-3p (P<0.05 vs control). WDP interventions reversed these alterations (P<0.05 vs model).

Conclusion

WDP exerts protective effects against aluminum-induced cognitive dysfunction potentially through modulating miR-124-3p/STAT3-TGF-β1/Smad3 signaling pathway.

Aluminum  /  Walnut-derived peptides  /  Cognitive dysfunction  /  MiR-124-3p  /  STAT3-TGF-β1/Smad3
Xiao-yu ZHANG, Xiu-feng WANG, Quan-yue WANG, Bing-yi WANG, Li LIN, Jing ZHANG, Huan LI. Walnut-derived peptides ameliorate aluminum-induced cognitive impairment via miR-124-3p/STAT3-TGF-β1/Smad3 signaling pathway in rats[J]. Modern Preventive Medicine, 2025 , 52 (13) : 2374 -2378 . DOI: 10.20043/j.cnki.MPM.202502076
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Year 2025 volume 52 Issue 13
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Article Info
doi: 10.20043/j.cnki.MPM.202502076
  • Receive Date：2025-02-07
  • Online Date：2026-03-19
  • Published：2025-07-10
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  • Received：2025-02-07
Funding
Affiliations
    School of Public Health and Health Management, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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