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To investigate the mediating effects of visceral fat rate and muscle rate on the relationship between menopausal age and blood glucose levels in naturally postmenopausal women, providing references for diabetes prevention.
Participants were selected from the Guangzhou Chronic Disease Prospective Cohort Study.Baseline data including demographic characteristics, menopausal status, visceral fat rate, muscle rate, fasting blood glucose and lipid profiles were collected.Generalized linear models were used to analyze the relationships between menopausal age and visceral fat rate, muscle rate, and blood glucose levels.
The study included 1 939 naturally postmenopausal women with menopausal age ≥46 years (mean age 59.1±5.1 years, mean menopausal age 50.9±2.4 years). After adjusting for confounders, menopausal age showed linear associations with visceral fat rate (β=0.054, 95%CI: 0.024-0.083), muscle rate (β=-0.113, 95%CI: -0.193 to -0.032), and blood glucose (β=0.032, 95%CI: 0.009-0.055). Visceral fat rate and muscle rate partially mediated the relationship between menopausal age and blood glucose, accounting for 17.04% and 11.65% of the total effect respectively.
Later menopausal age may influence blood glucose levels partially through increasing visceral fat accumulation and decreasing muscle mass in postmenopausal women.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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