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Association between Alpha-1-acid glycoprotein and prediabetes in adults
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Xiao-yan JIA1, Rui-jia LIAN2, Bao-dong MA3, Xi-wen MA4
Modern Preventive Medicine | 2025, 52(13) : 2491 - 2496
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Modern Preventive Medicine | 2025, 52(13): 2491-2496
• Clinical Medicine and Prevention •
Association between Alpha-1-acid glycoprotein and prediabetes in adults
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Xiao-yan JIA1, Rui-jia LIAN2, Bao-dong MA3, Xi-wen MA4
Affiliations
  • Department of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China
Published: 2025-07-10 doi: 10.20043/j.cnki.MPM.202501238
Outline
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Objective

To investigate the association between alpha-1-acid glycoprotein (AGP) and prediabetes prevalence in US adults.

Methods

We analyzed data from 2 926 participants (age ≥18 years) in the National Health and Nutrition Examination Survey (2017-2023). Participants were classified into prediabetes and non-prediabetes groups. AGP levels were measured and analyzed both as continuous and quartile-categorized variables. Weighted logistic regression models were employed to assess this relationship after adjusting for covariates.

Results

The prediabetes group showed significantly higher AGP levels (0.79±0.02) versus controls (0.78±0.01; P<0.001). In fully adjusted models, each unit increase in AGP was associated with 7.8% higher prediabetes risk (OR=1.08, 95%CI:1.453-1.842). Quartile analysis revealed progressively increasing risks from Q2 to Q4 versus Q1 (all P<0.05). Subgroup analyses showed stronger associations in females (OR=1.01,95%CI:1.095-2.778, P=0.043) and younger adults (18-39 years; OR=1.22, 95%CI:1.182-7.965, P=0.008).

Conclusion

Elevated AGP levels are consistently associated with increased prediabetes risk, suggesting its potential as a novel biomarker for early risk identification.

Alpha-1-acid glycoprotein  /  Prediabetes  /  NHANES database  /  Cross-sectional study
Xiao-yan JIA, Rui-jia LIAN, Bao-dong MA, Xi-wen MA. Association between Alpha-1-acid glycoprotein and prediabetes in adults[J]. Modern Preventive Medicine, 2025 , 52 (13) : 2491 -2496 . DOI: 10.20043/j.cnki.MPM.202501238
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Year 2025 volume 52 Issue 13
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Article Info
doi: 10.20043/j.cnki.MPM.202501238
  • Receive Date：2025-01-13
  • Online Date：2026-03-19
  • Published：2025-07-10
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  • Received：2025-01-13
Funding
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    Department of Geriatrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China
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