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A longitudinal association study of multimorbidity patterns with new-onset depressive symptoms based on latent class analysis
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Dan-ying CHEN1, Huan XU1, Zhong-ze FU2, Bing GUO1, Tao HU3
Modern Preventive Medicine | 2025, 52(12) : 2120 - 2125
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Modern Preventive Medicine | 2025, 52(12): 2120-2125
• Epidemiology and Statistical Methods Advances •
A longitudinal association study of multimorbidity patterns with new-onset depressive symptoms based on latent class analysis
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Dan-ying CHEN1, Huan XU1, Zhong-ze FU2, Bing GUO1, Tao HU3
Affiliations
  • Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2025-06-25 doi: 10.20043/j.cnki.MPM.202412368
Outline
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Objective

To explore the association between multimorbidity patterns and new-onset depressive symptoms in a community population in Sichuan.

Methods

Based on the follow-up data of a Southwest cohort, multimorbidity patterns were identified among 16 long-term diseases using latent class analysis. Logistic regression model was used to investigate the associations of multimorbidity status, number of multimorbidity, and specific multimorbidity patterns with new-onset depressive symptoms. Differences in these associations within subgroups of age, sex, frequency of alcohol consumption, smoking status, and level of green space were compared by stratified analyses.

Results

Multimorbidity status and number of multimorbidity were significantly associated with the risk of new-onset depressive symptoms with OR values of 1.46 (95% CI: 1.13-1.88) and 1.19 (1.09-1.29), respectively. Compared with hypertension multimorbidity pattern, hyperlipidemia multimorbidity and metabolic-skeletal multimorbidity were associated with the risk of depression onset with OR values of 1.69 (95% CI: 1.01-2.61) and 2.90 (95% CI: 1.47-5.71).

Conclusion

Multimorbidity can increase the risk of depression, and metabolic-skeletal multimorbidity has a higher risk of depression compared to hyperlipidemic multimorbidity.

Multimorbidity  /  Multimorbidity patterns  /  Depressive symptoms  /  Latent class analysis
Dan-ying CHEN, Huan XU, Zhong-ze FU, Bing GUO, Tao HU. A longitudinal association study of multimorbidity patterns with new-onset depressive symptoms based on latent class analysis[J]. Modern Preventive Medicine, 2025 , 52 (12) : 2120 -2125 . DOI: 10.20043/j.cnki.MPM.202412368
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Article Info
doi: 10.20043/j.cnki.MPM.202412368
  • Receive Date：2024-12-22
  • Online Date：2026-03-19
  • Published：2025-06-25
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  • Received：2024-12-22
Funding
Affiliations
    Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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