PDF
Full
Outline
To explore the potential causal relationship between gut microbiota and female infertility using the Mendelian randomization (MR) method and to determine the role of blood metabolites as potential mediators.
Gut microbiota data from 18 340 participants in 24 cohorts published by the MiBioGen Consortium, blood metabolite data from the Canadian Longitudinal Study of Aging (CLSA) cohort and Finnish R10 database on female infertility were used. The inverse variance weighting, weighted median, and MR-Egger regression method were used to investigate the causal relationship between 211 gut microbiota and 1 091 blood metabolites with female infertility. A two-step Mendelian randomization method was used to explore the potential mediating role of blood metabolites between gut microbiota and female infertility.
IVW results showed that 2 phyla, 1 class, 2 orders, 2 families, 12 genera of known gut microbiota were significantly causally associated with the female infertility. Among them, genus Lachnospira (OR=0.589, 95% CI: 0.361-0.961, P=0.035), genus Ruminococcus torques group (OR=0.756, 95% CI: 0.613-0.923, P=0.007), etc. showed a significant negative correlation with female infertility. Order Burkholderiales (OR=1.174, 95% CI: 1.062-1.284, P=0.001), genus Coprococcu2 (OR=1.174, 95% CI: 1.062-1.297, P=0.002), etc. showed a significant positive correlation with female infertility. Mediation analysis revealed that five blood metabolites could mediate the relationship between five gut microbiota and female infertility.
This study indicates that certain blood metabolites can mediate the relationship between gut microbiota and female infertility. Further investigations are warranted to explore the potential mechanisms underlying these associations.
PDF
58
26
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
