PDF
Full
Outline
To explore the association between frailty status and RA through trajectory analyses, and to provide a scientific basis for targeted measures to reduce the risk of RA.
Survey data from the 2004-2018 American Health and Retirement Study (HRS) were analyzed for potential categories of frailty using growth mixture models for the three waves of data from 2004-2010. Using 2010 as the baseline, four waves of data from 2010 to 2018 were tracked to analyze the association between different frailty statuses and participants’ RA risk, and Cox proportional risk models were used to describe the associations between different frailty states and the development of RA.
The baseline population totaled 3 677 individuals, including 1 337 (36.4%) males; 2 340 (63.6%) females. Four frailty trajectories were identified through growth mixture modeling, with a high frailty lowering group (10.6%), a persistent high frailty group (20.1%), a persistent low frailty group (34.0%), and a low frailty elevation group (35.3%). Analysis of Cox proportional risk regression modeling showed that, in the fully adjusted model with the low frailty elevation group as the reference, the persistent high frailty group had a 0.255-fold increased risk of developing RA 0.255-fold (HR=1.255, 95% CI: 1.001-1.576), and the risk of developing RA increased 0.422-fold in the high frailty-reduced group (HR=1.422, 95% CI: 1.071-1.888).
Frailty is a risk factor for RA, and the risk of developing RA is increased in the high frailty reduction group and the persistent high frailty group.
PDF
56
25
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
