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To explore the quantitative association and dose-response relationship between systemic immune inflammatory index (SII) and the risk of hypertension among petrochemical workers.
This cohort study included 2 386 occupational workers from a large petrochemical enterprise in southern China. Baseline data were collected in 2018 through occupational health monitoring, and follow-up data were obtained annually through regular physical exams until 2023. The study gathered demographic information, occupational exposure data, blood pressure, blood sugar, blood lipid levels, and SII results via questionnaires, hazard monitoring, physical exams, and laboratory tests. We used multivariate Cox proportional hazard regression models and restricted cubic spline analysis to examine the quantitative association and dose-response relationship between SII and new-onset hypertension. Stratified analyses were performed based on occupational exposure, age, and gender.
During the follow-up period, 645 new cases of hypertension were identified. SII was positively correlated with hypertension risk in a dose-dependent manner. The SII was categorized into three groups (T1, T2, and T3). After adjusting for covariates, the hypertension risk in the T2 and T3 groups was 1.40 (95% CI:1.16-1.70) and 1.30 (95% CI: 1.06-1.58), respectively, compared to the T1 group. The relationship between SII and hypertension risk followed a nonlinear, inverted U-shape: risk increased with higher SII values up to a point, then decreased (P=0.005, nonlinear P=0.007). Subgroup analysis revealed that the patterns observed in workers under 39 years old and male workers were consistent with the overall population. Noise exposure did not affect the association between SII and hypertension risk, but no such association was found among workers exposed to benzene and its homologs.
SII is positively correlated with hypertension risk in petrochemical workers in a dose-dependent manner, exhibiting a nonlinear dose-response relationship. These findings provide a basis for using SII in hypertension risk assessment and prevention strategies in petrochemical workers.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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