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To explore the association between metabolic score of insulin resistance (METS-IR) and the risk of Cardiometabolic multimorbidity (CMM) in middle-aged and elderly Chinese.
A population-based cohort study was conducted using data from the China Longitudinal Study of Health and Aging (CHARLS) among Chinese residents aged 45 years or older from 2011 to 2018. Cox proportional hazards regression models were used to calculate Hazard Ratio (HR) and 95% confidence intervals (CI) for the association between METS-IR and new CMM, and stratified analyses were performed in different populations to observe the interaction between covariates and METS-IR. The dose-response relationship between METS-IR and new CMM in different body weight population was observed with restricted cubic spline. Receiver operating characteristic (ROC) curve was constructed to analyze the value of METS-IR in predicting the risk of CMM.
A total of 5 349 subjects were included in this study, and the incidence of CMM was 2.08%. After adjusting for all included covariates, METS-IR as a continuous variable was positively correlated with the risk of CMM (HR: 1.07, 95%CI: 1.05-1.09, P<0.001). As a categorical variable, the highest METS-IR group was still positively associated with the risk of CMM (HR: 3.47, 95%CI: 2.06-5.84, P<0.001). In total participants (P for overall <0.001), normal weight (P for overall = 0.022) and overweight and obese (P for overall = 0.008) populations still had a linear relationship between MET-IR and CMM risk. METS-IR was predictive of CMM risk (AUC: 0.651, 95%CI: 0.598-0.704).
The study finds that METS-IR is positively associated with an increased risk of new CMM in middle-aged and older adults and should be of continued concern in both normal weight and overweight obese people to reduce the risk of CMM.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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