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Association between anxiety disorders and the risk of non-alcoholic fatty liver disease in Caucasians
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Xiao-rui ZHOU1, Lang LI2, Yue ZHENG3, Juan LIAO3, Lu LONG1
Modern Preventive Medicine | 2025, 52(5) : 826 - 830
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Modern Preventive Medicine | 2025, 52(5): 826-830
Epidemiology and Statistical Methods
Association between anxiety disorders and the risk of non-alcoholic fatty liver disease in Caucasians
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Xiao-rui ZHOU1, Lang LI2, Yue ZHENG3, Juan LIAO3, Lu LONG1
Affiliations
  • Department of Epidemiology and Health Statistics, West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2025-03-10 doi: 10.20043/j.cnki.MPM.202409542
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Objective

To investigate the association between anxiety disorders and the risk of developing non-alcoholic fatty liver disease (NAFLD) in Caucasians.

Methods

This study was a prospective cohort study based on the UK Biobank database.Individuals who were not Caucasian, had missing racial information, had liver disease at baseline, had alcohol/drug use disorders or missing relevant diagnosis dates, or developed NAFLD within two years of follow-up were excluded, resulting in a total of 465 621 participants for analysis. The baseline survey conducted from 2006 to 2010 served as the starting point for follow-up, with NAFLD incidence, loss to follow-up, death, or end of follow-up as the endpoints. A multivariable Cox proportional hazards regression model was used to explore the association between anxiety disorders and the risk of developing NAFLD.

Results

The participants accumulated 6 058 222 person-years of follow-up, with a median follow-up time of 13.50 years. There were 5 184 cases of NAFLD, with an incidence density of 8.56 cases per 10 000 person-years. After adjusting for covariates, the risk of developing NAFLD in individuals with anxiety disorders was increased by 0.75 times compared to those without anxiety disorders (HR=1.75, 95%CI: 1.32-2.32).

Conclusion

Anxiety disorders are associated with an increased risk of developing NAFLD in Caucasians, highlighting the need for enhanced clinical monitoring and prevention of NAFLD in patients with anxiety disorders.

Anxiety disorders  /  Non-alcoholic fatty liver disease  /  Survival analysis  /  Cohort study
Xiao-rui ZHOU, Lang LI, Yue ZHENG, Juan LIAO, Lu LONG. Association between anxiety disorders and the risk of non-alcoholic fatty liver disease in Caucasians[J]. Modern Preventive Medicine, 2025 , 52 (5) : 826 -830 . DOI: 10.20043/j.cnki.MPM.202409542
Year 2025 volume 52 Issue 5
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doi: 10.20043/j.cnki.MPM.202409542
  • Receive Date:2024-09-29
  • Online Date:2026-03-18
  • Published:2025-03-10
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  • Received:2024-09-29
Affiliations
    Department of Epidemiology and Health Statistics, West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
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占总种数比例
Percentage of
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种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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