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To evaluate the clinical value of maternal liver function indicators combined with umbilical artery blood flow parameters in diagnosing fetal growth restriction (FGR).
This study employed a case-control design, including pregnant women who underwent prenatal examinations and delivered at Southern Hospital of Southern Medical University from December 2017 to July 2022. The case group consisted of 172 pregnant women clinically diagnosed with FGR, while the control group included 292 pregnant women with normal pregnancies who were examined at the same hospital during the same period. Maternal late-pregnancy liver function indicators and umbilical artery blood flow parameters were collected. Multivariate logistic regression analysis was conducted to assess the association of these indicators with the risk of FGR. The performance of each indicator and the combined model was evaluated using receiver operating characteristic curves, net reclassification improvement index, and integrated discrimination improvement index.
In this study, pregnant women in the FGR group had significantly higher levels of ALT, ALB, and S/D ratio of umbilical artery blood flow compared to the control group. Multivariate logistic regression analysis indicated that ALT (OR=1.744, 95%CI: 1.332-2.283), ALB (OR=1.290, 95%CI: 1.002-1.661), and S/D ratio (OR=1.778,95%CI: 1.324-2.387) were significant risk factors for FGR, and the combined model of these three indicators exhibited high diagnostic value for fetal growth restriction.
Maternal liver function indicators (ALT, ALB) and umbilical artery blood flow parameters (S/D ratio) are associated with the risk of FGR, and the combined analysis of these factors can significantly enhance the diagnostic efficiency for FGR.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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