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To analyze the disease burden of patients with cervical cancer (CC) and precancerous lesions in Suzhou in 2022,evaluate the cost-effectiveness of different human papillomavirus (HPV) vaccines, and explore the optimal vaccination mode in Suzhou.
A retrospective survey was conducted to investigate the medical expenses and hospitalization costs of patients with CC and precancerous lesion in Suzhou City in 2022. Using the PRME model, we evaluated the cost-effectiveness of different immunization strategies and combined sensitivity analysis to determine the optimal solution.
Assuming that 13-year-old girls in Suzhou received domestic bivalent HPV vaccine (2vHPV) or 9-valent HPV vaccine (9vHPV) in 2022, and the vaccination rate reached 90.00%, the model predicted that it could avoid 77-103 cases of CC and 17-23 deaths in the future, saving 42.54-56.64 disability-adjusted life years (DALYs). Compared with not receiving the vaccine, the incremental cost-effectiveness ratio (ICER) of 2vHPV and 9vHPV was 10 423.54 yuan/DALYs and 131 348.23 yuan/DALYs, respectively, and both were cost-effective.
Both 2vHPV and 9vHPV are cost-effective. Compared to 9vHPV, vaccinating 13-year-old girls with 2vHPV is a more cost-effective vaccination strategy. The cost of vaccines plays a crucial role in determining the ICER. When the price of 9vHPV drops below 90.50 yuan per dose, its ICER becomes lower than that of 2vHPV at 63.00 yuan per dose. Therefore, reducing HPV vaccine prices through government negotiation, centralized procurement, and promoting domestic vaccines is recommended.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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