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To investigate the correlation and dose-response relationship of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with type 2 diabetes mellitus (T2DM) in the elderly aged over 65 years.
The participants were from the medical examination of the elderly aged 65 years and over in Wujin district, Changzhou city in 2022. The survey contents included questionnaire survey, physical examination and laboratory examination. Logistic regression and restricted cubic spline were used to analyze the correlation and dose-response relationship of NLR and PLR with T2DM.
A total of 112 073 individuals were included in this study, with an average age of 72.66±5.62 years. Among them, 53 557 (47.79%) were male, and 16 935 (15.11%) were T2DM patients. After adjusting for relevant confounding factors, compared with the Q1 group of PLR, the ORs (95% CI) for T2DM in the Q2, Q3, and Q4 groups were 0.93 (0.88-0.97), 0.83 (0.79-0.87), and 0.73 (0.70-0.77).respectively (P fortrend <0.001). Compared with the Q1 group of NLR, the ORs (95% CI) for T2DM in the Q2, Q3, and Q4 groups were 1.12 (1.06-1.18), 1.19 (1.13-1.25), and 1.35 (1.28-1.42), respectively (P fortrend <0.001). Subgroup analysis results showed that the established in this study demonstrates notable advantages, including simple operation, rapid reaction, high specificity, superior sensitivity, and low cost, and does not rely on specialized nucleic acid detection equipment, but only requires a thermostatic heating instrument to complete the detection. The method is suitable for the immediate detection of arthropod-borne viruses, offering a novel technical platform for arbovirus identification.correlation between PLR and NLR and T2DM remained statistically significant across subgroups stratified by sex, age, hypertension, BMI, and abdominal obesity (all P-values < 0.05). Hypertension status and gender had significant interactions with the association between PLR, NLR and T2DM (P forinteraction < 0.05). The results of the restricted cubic spline showed that PLR had a negative nonlinear relationship with the prevalence of T2DM (P=0.008), and NLR had a positive nonlinear relationship with the prevalence of T2DM (P<0.001). The threshold effect inflection points of PLR and NLR on T2DM were 158.0 and 2.47 respectively (log-likelihood ratio test P<0.05).
The risk of T2DM increased with the increase of NLR and decreased with the increase of PLR. This study also found nonlinear dose-response relationships between NLR, PLR and T2DM.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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