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The mediating role of the number of somatic pain sites in the relationship between chronic disease count and depressive symptoms among the elderly
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Yi-qian WU1, Qi JING2, Wen-yu SU1, Xin-yi ZHANG1, Ru-xu GE2, Li-hong JI1, Zhi-wei DONG2, Wen-gui ZHENG1
Modern Preventive Medicine | 2025, 52(16) : 3035 - 3039
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Modern Preventive Medicine | 2025, 52(16): 3035-3039
Clinical Medicine and Prevention
The mediating role of the number of somatic pain sites in the relationship between chronic disease count and depressive symptoms among the elderly
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Yi-qian WU1, Qi JING2, Wen-yu SU1, Xin-yi ZHANG1, Ru-xu GE2, Li-hong JI1, Zhi-wei DONG2, Wen-gui ZHENG1
Affiliations
  • School of Public Health, Shandong Second Medical University, Weifang, Shandong 261053, China
Published: 2025-08-25 doi: 10.20043/j.cnki.MPM.202503011
Outline
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Objective

To explore whether the number of somatic pain sites serves as a mediator between the number of chronic conditions and depressive symptoms in older adults.

Methods

Based on data from the 2020 wave of the China Health and Retirement Longitudinal Study (CHARLS), 8 363 participants aged 60 and above were analyzed. The mediating role between variables was examined using Model 4 of the PROCESS 4.0 macro, and the Bootstrap method was applied for validation.

Results

The prevalence of depressive symptoms among older adults reached 41.02%. An increase in both chronic disease count and pain site number was significantly associated with higher levels of depressive symptoms. (r1=0.284, r2=0.350, both P<0.001). A positive correlation was also observed between the number of chronic diseases and the number of pain sites (r3=0.381, P<0.001).The mediation analysis results indicate that the number of pain sites (effect size=0.15, Bootstrap 95%CI: 0.13-0.18) mediated the relationship between the number of chronic diseases and depressive symptoms.

Conclusion

Both the number of chronic diseases and the number of pain sites are important factors influencing depressive symptoms in the elderly, with the number of pain sites playing a partial mediating role between the two. It is recommended to strengthen pain management in the elderly, regularly assess pain status, provide personalized interventions, and incorporate psychological support to enhance the quality of life and promote mental health in elderly individuals.

Elderly  /  Number of chronic diseases  /  Number of pain sites  /  Depressive symptoms  /  Mediating effect
Yi-qian WU, Qi JING, Wen-yu SU, Xin-yi ZHANG, Ru-xu GE, Li-hong JI, Zhi-wei DONG, Wen-gui ZHENG. The mediating role of the number of somatic pain sites in the relationship between chronic disease count and depressive symptoms among the elderly[J]. Modern Preventive Medicine, 2025 , 52 (16) : 3035 -3039 . DOI: 10.20043/j.cnki.MPM.202503011
Year 2025 volume 52 Issue 16
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doi: 10.20043/j.cnki.MPM.202503011
  • Receive Date:2025-03-01
  • Online Date:2026-03-18
  • Published:2025-08-25
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  • Received:2025-03-01
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    School of Public Health, Shandong Second Medical University, Weifang, Shandong 261053, China
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表12种不同金属材料的力学参数

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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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