To assess the relationship between the Life’s Crucial 9 (LC9) and stress urinary incontinence (SUI).

Data based on 4 550 participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2018 were analyzed. Subjects were categorized into T1, T2, and T3 groups based on LC9 tertiles. Logistic regression analysis was used to explore the relationship between LC9 and SUI with parallel trend analysis. Stratified Logistic regression was used to analyze the correlation between LC9 and SUI in different groups. Restricted cubic spline was used to explore the quantitative relationship between LC9 and SUI.

All three models showed a negative correlation between LC9 and SUI incidence (all P<0.001). After adjusting for various covariates, each 10-point increase in LC9 was associated with a 16% reduction in SUI incidence (OR=0.84, 95% CI: 0.79-0.88). T3 was associated with a 40% reduction in SUI incidence compared with T1 (OR=0.60, 95% CI: 0.50-0.72). The results of restricted cubic spline curve (RCS) analysis further showed a significant linear negative association between LC9 and SUI incidence after adjustment for relevant variables (overall P<0.001; nonlinear P=0.261). There was a significant interaction between LC9 score and history of vaginal delivery (P<0.05). Higher LC9 scores in patients with SUI (n=2 047) were significantly associated with mortality from cardiovascular events in SUI (HR=0.10, 95% CI: 0.01-0.79).

LC9 is negatively associated with morbidity and mortality from SUI, and good quality of life management may be a potential strategy to reduce SUI incidence and mortality.