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To analyze the recurrence status and influencing factors of initially treated elderly tuberculosis patients after successful treatment in Kashgar region, and to provide a basis for preventing and controlling tuberculosis recurrence.
A total of 40 527 Patients aged 60 and above who were initially treated for tuberculosis and successfully treated in Kashgar from 2016 to 2022 were selected as the study subjects. Their recurrence rate up to the end of 2023 was analyzed. The Kaplan-Meier method was used for univariate analysis of recurrence influencing factors, the log-rank test was used for inter-group comparison, and the Cox proportional hazards regression model was used for multivariate analysis. Results Among the 40 527 study participants, 6 358 cases of recurrence were recorded by the end of 2023, with a total cumulative recurrence rate of 19.17%. The Cox proportional hazards regression model showed that male gender (aHR=1.176, 95%CI: 1.119-1.235), severe tuberculosis burden in the current residence (aHR=1.354, 95%CI: 1.234-1.486), positive sputum test result at initial diagnosis (aHR=1.831, 95%CI: 1.622-2.068), positive sputum test result at the end of the second month of initial treatment (aHR=2.230, 95%CI: 1.736-2.865), positive sputum culture result at initial diagnosis (aHR=1.533, 95%CI: 1.346-1.745), and a diagnosis and treatment delay of 30 days or more (aHR=1.126, 95%CI: 1.057-1.198) were independent risk factors for recurrence in initially treated elderly tuberculosis patients. In contrast, active case-finding (aHR=0.635, 95%CI: 0.600-0.672), a cured treatment outcome (aHR=0.655, 95%CI: 0.580-0.739), and puretuberculous pleurisy (aHR=0.206, 95%CI: 0.098-0.432) were protective factors against recurrence.
To reduce the recurrence of initially treated elderly tuberculosis, it is necessary to strengthen follow-up and management after treatment, implement targeted interventions for high-risk groups, and enhance public health education to promote early detection and standardized treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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