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To analyze the relationship between the ratio of glycated albumin to glycated hemoglobin (GA/HbA1c)and all-cause mortality in adults with metabolic syndrome MetS.
This study is a retrospective cohort study utilizing data from the National Health and Nutrition Examination Survey (NHANES) and the National Death Index (NDI) from 1999 to 2004. A total of 1 497 eligible participants were included and followed up until December 31, 2019. The relationship between the GA/HbA1c ratio and all-cause mortality in MetS patients was assessed using Kaplan-Meier survival curves, multivariable weighted Cox regression, and restricted cubic splines.
Among a weighted population of 55 224 898 eligible individuals with a median follow-up of 16.3 years, there were 501 cases of all-cause mortality. Participants were divided into three groups(T1, T2, T3) based on weighted tertiles of the GA/HbA1c ratio. After adjusting for covariates, a higher GA/HbA1c ratio (T3) was associated with an increased risk of all-cause mortality in MetS patients compared to the lowest tertile (T1) (HR=1.335, 95%CI:1.010-1.772). The restricted cubic spline analysis also revealed a non-linear “S” shaped relationship between the GA/HbA1c ratio and all-cause mortality (non-linear P<0.05). Subgroup analyses (all interaction P>0.05) and sensitivity analyses (HR=1.344, 95%CI: 1.014-1.783) showed similar results.
There is a non-linear association between the GA/HbA1c ratio and all-cause mortality in patients with metabolic syndrome, with higher GA/HbA1c ratios linked to an increased risk of all-cause mortality in these patients.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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