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To explore the relationship between depression and angina pectoris, as well as the mortality risk associated with their comorbidity, providing references for the treatment and prognostic management of angina pectoris patients.
Based on the National Health and Nutrition Examination Survey (NHANES) database from 2009 to 2018, data from 11 232 individuals aged 40 and older were analyzed using logistic regression and restricted cubic spline models to investigate the relationship between depression and angina pectoris. Survival curves (Kaplan-Meier) and Cox regression models were employed to examine the differences in mortality risk among four groups.
Logistic regression analysis revealed statistically significant risks of angina pectoris across various depression groups (mild depression group OR=1.78, 95%CI: 1.48-2.20; moderate depression group OR=3.40, 95%CI: 2.62-4.42; severe depression group OR=5.16, 95%CI: 3.94-6.77), indicating that higher levels of depression correlate with greater risk of angina pectoris (W=151.93, P<0.001), suggesting that depression was a risk factor for angina pectoris. In the overall population, the dose-response relationship between the two exhibited a gradually decreasing slope, indicating an increasing trend in angina pectoris risk with worsening depression. The Kaplan-Meier curves and Cox regression models demonstrated that the mortality risk in the comorbid depression and angina pectoris group was higher than that in the depression-only and angina pectoris-only groups, even after adjusting for all potential confounding factors (HR=2.35, 95%CI: 1.77-3.12).
There is a significant correlation between depression and angina pectoris, with the mortality risk in the comorbid depression and angina pectoris group being higher than in either the depression-only or angina pectoris-only groups. Future treatment of angina pectoris should also emphasize the assessment, prevention, and treatment of depression to improve long-term patient outcomes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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