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To explore the association between Triglyceride Glucose-Body Mass Index (TyG-BMI) and the risk of developing type 2 diabetes mellitus (T2DM).
The data were obtained from the natural population cohort of Shanghai suburbs established from April 2016 to September 2017 (Songjiang subcohort). 29,351 nondiabetic subjects with normal blood glucose levels aged 20-74 years at baseline were included in the analysis. The association and dose-response relationship between baseline TyG-BMI level and the risk of developing T2DM were assessed by Cox proportional risk regression model and restricted cubic spline model. Covariates such as gender and age were stratified according to their covariates and their interaction with TyG-BMI was analyzed.
A total of 584 men and 777 women were initially diagnosed with T2DM after a median follow-up time of 6.98 years. After correcting for confounders, the Cox regression model showed a 58% increase in the risk of T2DM incidence for every 1 SD increase in TyG-BMI (HR=1.58, 95% CI: 1.50-1.66). After grouping TyG-BMI by quartiles and then including it as a categorical variable in the Cox regression model analysis, the risk of T2DM incidence increased progressively in the Q2, Q3, and Q4 groups with HR (95% CI) of 1.42 (1.15-1.75), 2.02(1.66-2.46), and 3.47(2.88-4.19), respectively (Ptrend<0.001), using the Q1 group as the control. Restricted cubic spline plots showed a nonlinear association between TyG-BMI and the risk of T2DM incidence (Pnonlinear =0.048). In addition, subgroup analyses showed that the association between TyG-BMI and the risk of developing T2DM was significantly higher in young and middle-aged (less than 60 years old) residents than in older residents (Pinteraction < 0.05).
Under normal blood glucose levels, baseline TyG-BMI was positively associated with the risk of developing T2DM, and this association was more significant in the young and middle-aged groups.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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