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A Mendelian randomization study on the relationship between handgrip strength in both hands and cognitive function
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Yi-nuo ZHOU, Rui MA, Ke-rui WANG, Shao-hui SU, Si-ran CHEN, Meng-qi ZHOU, Yan-fang YANG
Modern Preventive Medicine | 2024, 51(24) : 4454 - 4458
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Modern Preventive Medicine | 2024, 51(24): 4454-4458
A Mendelian randomization study on the relationship between handgrip strength in both hands and cognitive function
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Yi-nuo ZHOU, Rui MA, Ke-rui WANG, Shao-hui SU, Si-ran CHEN, Meng-qi ZHOU, Yan-fang YANG
Affiliations
  • Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2024-12-25 doi: 10.20043/j.cnki.MPM.202410061
Outline
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Objective

To explore the causal relationship between left and right handgrip strength and the onset of cognitive decline, providing a reference for developing strategies to prevent cognitive decline in the elderly.

Methods

Genome-wide data for left and right handgrip strength were obtained from the UK Biobank, while genome-wide data for cognitive function were sourced from a meta-analysis conducted by the Cognitive Genomics Consortium. The study employed three regression models: Inverse-Variance Weighted (IVW), MR-Egger regression, and Weighted Median, to conduct Mendelian randomization analyses on the causal relationship between left and right handgrip strength and cognitive function.

Results

The IVW model results demonstrated a positive causal relationship between right handgrip strength (β=0.08, 95% CI: 0.03-0.14, P=0.004), left handgrip strength (β=0.08, 95% CI: 0.01-0.14, P=0.017), and cognitive function.

Conclusion

The findings of this study support a positive causal relationship between left-hand grip strength, right-hand grip strength, and cognitive function.

Handgrip strength  /  Cognitive function  /  Mendelian randomization  /  Causality
Yi-nuo ZHOU, Rui MA, Ke-rui WANG, Shao-hui SU, Si-ran CHEN, Meng-qi ZHOU, Yan-fang YANG. A Mendelian randomization study on the relationship between handgrip strength in both hands and cognitive function[J]. Modern Preventive Medicine, 2024 , 51 (24) : 4454 -4458 . DOI: 10.20043/j.cnki.MPM.202410061
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Year 2024 volume 51 Issue 24
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Article Info
doi: 10.20043/j.cnki.MPM.202410061
  • Receive Date：2024-10-09
  • Online Date：2026-03-18
  • Published：2024-12-25
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  • Received：2024-10-09
Affiliations
    Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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