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To analyze the genotypes and characteristics of HIV-1 transmission network of newly reported HIV/AIDS cases aged 50 and above in Yubei District of Chongqing and provide evidence for effective HIV-1 transmission prevention in Yubei District.
Blood sample of newly reported cases aged 50 and above in 2020-2023 were collected for genetic analysis, partial Pol gene sequences were obtained to construct molecular transmission network. The factors associated with the subjects entering network and characteristics of cluster were further analyzed.
A total of 351 Pol gene sequences were obtained and 9 HIV-1 genotypes were detected. CRF07_BC (57.0%, 200/351) was the major subtypes, followed by CRF08_BC(19.4%, 68/351), the rate of network entry was 57.3%, and 44 clusters were formed. The number of nodes in clusters was between 2-25. People aged 60 and above (60-69years old: aOR=2.25, 95% CI: 1.34-3.80; 70-79years old: aOR=2.93,95% CI: 1.52-5.65), with local household registration in Yubei (aOR=3.10, 95% CI: 1.74-5.52) and genotype CRF07_BC (aOR=2.57, 95% CI: 1.47-4.50) were more likely to have internet access. The proportion of high-risk spreaders was higher among males than among females.
CRF07_BC and CRF08_BC are the major genotypes of HIV/AIDS in people aged 50 years and abovein Yubei District, and CRF07_BC is the genotype of key transmission cluster with high transmission risk.We should strengthen the intervention for the high-risk elderly, and monitor the molecular network dynamically to guide the precise intervention.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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