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To investigate the status of drug resistance of Mycobacterium tuberculosis(M.tuberculosis) isolated from drug resistance monitoring stations in Changsha from 2021 to 2023, and to provide reference for the control effect of drug-resistant tuberculosis.
The positive specimens from designated medical institutions in Changsha were collected and sent to our hospital together with the basic information of patients for further M.tuberculosis drug susceptibility test. Drug susceptibility tests were performed on all samples by proportional method, including 8 drugs, such as RFP, INH, EMB, SM, OFX, PAS, TH, KM, etc, and the qualitative data were analyzed by χ2 test.
Among the 3 037 isolates, 2 534 were fully sensitive and 503 were drug-resistant, and the total drug resistance rate was 16.56%. Among them, 316 were single drug resistant, and the drug resistance rate was 10.41%. There were 81 multi-drug resistant strains (2.67%) and 106 poly-drug resistant strains (3.49%). The drug resistance sequences of any drug were INH, SM and RFP, 9.02%, 6.98% and 3.65%, respectively. The top three of multi-drug resistant patterns were INH+RFP (0.66%), INH+RFP+SM (0.4%) and INH+RFP+SM+EMB (0.36%), respectively. The top three poly-drug resistant patterns were INH+SM (1.15%), INH+TH1321 (0.4%) and INH+EMB (0.2%), respectively. In addition, from year of 2021 to 2023, the resistance of M.tuberculosis to RFP, EMB, and TH1321 drugs in Changsha area showed a decreasing trend year by year (P<0.05), but the overall resistance rate of patients in Changsha urban area was significantly higher than that in other districts and counties.
Compared with other provinces and cities, the overall drug resistance rate of tuberculosis patients in Changsha is low, but the drug resistance rate of tuberculosis in Changsha urban area is significantly higher than that in other districts and counties, which should arouse the attention of relevant departments.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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