To explore the trends in cognitive function and depression symptoms over time among middle-aged and older adults in China, and to identify populations with differing trajectories of cognitive function and depression symptoms, thereby providing a scientific basis for formulating targeted prevention and control measures.
A total of 11 863 individuals aged 45 and above from the China Health and Retirement Longitudinal Study (CHARLS) were included. The Group-based Dual Trajectory Model (GBDTM) was employed to identify the developmental trajectories of cognitive function and depression symptoms, and multinomial logistic regression analysis was utilized to examine the influencing factors of different trajectories.
The GBDTM identified four trajectory groups: “Poor cognitive function but mild depression symptoms” (Group 1, 32.9%),“Poor cognitive function and severe depression symptoms” (Group 2, 10.8%), “Good cognitive function and mild depression symptoms” (Group 3, 40.5%), and “Moderate cognitive function and moderate depression symptoms” (Group 4, 15.7%). Factors associated with a higher likelihood of being classified in the“Poor cognitive function and severe depression symptoms” group included being female (OR=4.70, 95%CI: 3.82-5.78), unmarried (OR=2.09, 95%CI: 1.67-2.60), residing in rural areas (OR=4.26,95%CI: 3.59-5.07), smoking (OR=1.26, 95%CI: 1.02-1.56), having activities of daily living (ADL) disabilities (OR=1.92, 95%CI:1.39-2.65), and having instrumental activities of daily living (IADL) disabilities (OR=7.43, 95%CI: 5.90-9.35).
There is a partially “joint development” trajectory relationship between cognitive function and depression symptoms in middle-aged and older adults. Early intervention targeting the influencing factors of different trajectory groups is crucial.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |