PDF
Full
Outline
To explore the relationship between gaseous air pollutants and inflammatory indices in patients with schizophrenia (SCZ).
A total of 866 hospitalized SCZ patients were included from October 2020 to December 2023.The daily average exposure values of gaseous air pollutants (SO2, NO2, O3, CO) for the seven days prior to hospitalization were estimated using Kriging interpolation. Based on the biochemical test results on the day of admission, four inflammatory indices were calculated for the SCZ patients: Platelet to Lymphocyte Ratio (PLR), Neutrophil to Lymphocyte Ratio (NLR), Systemic Immune Inflammation Index (SII), and Systemic Inflammation Response Index (SIRI). Spearman correlation and multiple linear regression models were employed to analyze the association between individual gaseous air pollutants and inflammatory indices;Bayesian Kernel Machine Regression (BKMR) was used to assess the joint effects of mixed gaseous air pollutants on inflammatory indices.
The daily average exposure values of SO2, NO2, and CO in the seven days prior to hospitalization showed a positive correlation with PLR（rSO-PLR=0.08;rNO-PLR= 0.069; rCO-PLR=0.078）、NLR（rSO-NLR=0.075; rNO-NLR= 0.077; rCO-NLR=0.069） and SII（rSO-SII=0.081; rNO-SII=0.072; rCO-SII=0.075）, with statistical significance (all P<0.05). The multiple linear regression results indicated a positive correlation between the daily average NO2 exposure and NLR levels, with β=0.006(95%CI: 0.001-0.011). The BKMR analysis revealed that when the daily averages of the four gaseous air pollutants exceeded their 50th percentile (P50) in the seven days prior to hospitalization, the mixture of SO2, NO2, CO, and O3 had a positive joint effect on the NLR and SII of SCZ patients.
Short-term exposure to a mixture of gaseous air pollutants may influence the inflammatory response in SCZ patients.
PDF
48
21
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
