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To analyze the correlation between changes in uric acid trajectories in a male population undergoing health check-ups and the occurrence of hypertension, diabetes, and dyslipidemia.
This study selected 5 316 male subjects who met the inclusion and exclusion criteria from the Health Management Center of The Second Affiliated Hospital of Dalian Medical University over a ten-year period from 2012 to 2022. A group-based trajectory model (GBTM) was constructed based on uric acid levels, and the Cox proportional hazards regression model was utilized to analyze the risks of developing hypertension, diabetes, and dyslipidemia across different uric acid trajectory groups.
The study participants were categorized into low stable, low increasing, moderate increasing, and high increasing groups. The incidence of hypertension in the high increasing group was significantly higher than that in the low stable group. After adjusting for confounding factors, the Cox proportional hazards regression analysis indicated that the risk of developing hypertension in the high increasing group was 1.51 times (95%CI: 1.20-1.91, P<0.001) compared to the low stable group. However, no significant correlation was found between changes in uric acid trajectories and the occurrence of diabetes. A significant correlation was observed between changes in uric acid trajectories and dyslipidemia; as uric acid levels increased, the incidence of dyslipidemia also rose. After adjusting for confounding factors, the Cox proportional hazards regression analysis revealed that the risk of developing dyslipidemia in the high increasing group was 1.75 times (95%CI: 1.44-2.12, P<0.001) compared to the low stable group.
Among male individuals undergoing health check-ups, there is a correlation between uric acid trajectories and hypertension as well as dyslipidemia, yet no significant correlation with the occurrence of diabetes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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