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To explore the association between blood pressure levels and the risk of stroke-related death in type 2 diabetic population.
A survey was carried out on 9 708 type 2 diabetic patients who participated in the chronic disease patient health management of basic public health services in Huai’an District and Qing jiang pu District (former Qing he District) of Huai’an city. Multivariate proportional-hazards Cox regression analysis was used to analyze the association between blood pressure levels and the risk of stroke-related death in type 2 diabetic patients, and further stratified analysis was carried out according to smoking, body mass index (BMI), central obesity, and dyslipidemia respectively. The follow-up duration was calculated from December 31, 2013 to December 31, 2020, and death from stroke (I60-I69) was defined as the end-point event.
The follow-up duration was 63 833.8 person-years, and the stroke death density was 5.4 per 1 000 person-years. After adjusting for relevant confounding factors, taking the normal blood pressure group as the reference, the HR value of the stroke-related death risk in the grade III hypertension group was 4.45 (95%CI: 2.09-9.48). The stratified analysis results showed that compared with the normal blood pressure group, among smokers, those with BMI ≥ 24.0 kg/m2, those with central obesity, and those with dyslipidemia, the stroke-related death risks in the grade III hypertension group increased by 3.12 (HR=4.12, 95%CI:1.16-14.67), 1.97 (HR=2.97, 95%CI: 1.26-7.00), 3.19 (HR=4.19, 95%CI: 1.27-13.86), and 5.49 (HR=6.49, 95%CI: 1.97-21.43) times, respectively. Sensitivity analysis was carried out by excluding the baseline stroke patients, participants who died in the first year of follow-up, and those over 80 years old, and a significant positive relationship between blood pressure levels and the risk of stroke-related death was found.
Elevated blood pressure levels will increase the risk of stroke-related death in type 2 diabetic patients, and there is a positive relationship between blood pressure levels and the risk of death. Among type 2 diabetic patients, those with low BMI have a higher risk of stroke-related death than those with high BMI.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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