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To investigate the impact of serum free fatty acids (FFA) on serum uric acid (SUA) levels in young and middleaged hyperuricemia (HUA) patients with different body mass indexes (BMI).
A total of 144 young and middle-aged male patients first diagnosed with HUA at Zhu Xianyi Memorial Hospital of Tianjin Medical University from March 2018 to May 2020 were selected. They were divided into three groups based on BMI: normal group (18.5 kg/m2 ≤ BMI < 24.0 kg/m2, n=42), overweight group (24.0 kg/m2 ≤ BMI < 28.0 kg/m2, n=58), and obese group (BMI ≥ 28 kg/m2, n=44). Additionally, they were categorized into tertiles based on FFA levels: low tertile group (FFA ≤ 0.37 mmol/L, n=48), middle tertile group (0.37 mmol/L < FFA < 0.7 mmol/L, n=48),and high tertile group (FFA ≥ 0.7 mmol/L, n=48). General information and laboratory data, including FFA and SUA levels, were collected and statistically analyzed.
As BMI increased, FFA levels in the normal, overweight, and obese groups showed a significant upward trend (P < 0.05). SUA levels also increased, with statistically significant differences between the normal and obese groups and between the overweight and obese groups (P < 0.05), but no significant difference was observed between the normal and overweight groups (P > 0.05). With increasing FFA levels, BMI and SUA levels in the low, middle, and high FFA tertile groups also increased. Significant differences were observed between the low and high tertile groups and between the middle and high tertile groups (P < 0.05), but no significant difference was found between the low and middle tertile groups (P > 0.05). Two-way ANOVA revealed an interaction between FFA and obesity on the SUA levels (F=2.701, P=0.033), indicating that their combined effect further elevated SUA levels. Spearman correlation analysis showed a positive correlation between FFA and SUA levels in the obese group (r=0.428, P=0.004). However, no such correlation was observed in the normal and overweight groups (P > 0.05).
In young and middle-aged HUA patients, those with obesity and high FFA levels exhibit higher SUA levels. The effects of FFA and obesity on SUA levels are both additive and interactive.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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