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To analyze the relationship between residual cholesterol (RC) and metabolically associated fatty liver disease (MAFLD) in the elderly population of Zhongshan, and to explore the potential application value of RC in the diagnosis of MAFLD in older adults.
A cluster sampling method was employed to select elderly individuals aged 60 and above who underwent health check-ups at two community hospitals in Zhongshan, Guangdong Province. Baseline data were collected through questionnaire surveys, physical examinations, and laboratory tests. Multivariable logistic regression analysis was used to assess the association between RC and MAFLD, and a restricted cubic spline model was utilized to further analyze the dose-response relationship between RC and MAFLD.
A total of 6 756 elderly individuals were recruited, with an overall prevalence of MAFLD at 31.0%, higher in females (35.0%) than in males (24.7%). After adjusting for confounding factors, logistic regression analysis indicated that RC, treated as a continuous variable (OR: 1.70, 95%CI: 1.47-1.97), was positively associated with the risk of MAFLD. As a categorical variable, the highest RC group (OR: 2.13, 95%CI: 1.72-2.63) also showed a positive correlation with MAFLD risk. A non-linear relationship was observed between RC levels and MAFLD (P overalltrend <0.001, P non-linearity < 0.05), with a more pronounced risk increase in males (male OR: 1.83, 95%CI: 1.42-2.38 vs. female OR: 1.64,95%CI: 1.36-1.96).
RC is an independent risk factor for MAFLD in the elderly, and there exists a non-linear dose-response relationship between the two. The impact of RC levels on MAFLD risk is particularly significant in elderly males. Monitoring and managing RC is of great clinical significance in the prevention and treatment of MAFLD in older adults.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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