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To evaluate the associations between circulating monounsaturated fatty acids(cMUFAs) and cardiovascular-specific death using epidemiological methods.
This study included 36 254 patients with cardiovascular disease from the UK Biobank. Cox proportional hazards models were employed to examine the associations between cMUFAs and various fatalities, including cardiovascular death, ischaemic heart disease death, stroke death, cancer death, and all-cause death. Moreover, the study examined the dose-response relationship between cMUFAs and outcomes using quartiles, deciles, and restricted cubic splines. A subgroup analysis was conducted to validate the effects of cMUFAs on cardiovascular-specific deaths across different subgroups.
A positive correlation was observed between cMUFAs and all-cause death (HR=1.556, 95% CI: 1.419-1.705), as well as CVD (HR=1.504, 95% CI: 1.261-1.794), IHD (HR=1.572, 95% CI: 1.265-1.953), and cancer death (HR=1.291, 95% CI: 1.109-1.502). However, no significant association was found between cMUFAs and stroke death (P=0.582). The study revealed the existence of non-linear relationships between cMUFAs and cardiovascular-specific death. Subgroup analyses indicated that the association with all-cause death was more pronounced in females and current smokers. Furthermore, individuals aged over 50 years demonstrated a more pronounced correlation with IHD death.
In patients with cardiovascular disease, elevated levels of cMUFAs are associated with an increased risk of CVD death, IHD death, cancer death, and all-cause death. This association demonstrates a non-linear correlation trend.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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