To assess the association between the cardiometabolic index (CMI) and the risk of kidney stone prevalence, and to analyze its role across different population subgroups.
This cross-sectional study included health examination data from 76 624 adults. The association between CMI and the risk of kidney stones was evaluated using multivariable logistic regression models. Stratified analyses were conducted to explore the effect of different population characteristics. A piecewise linear regression model was used to assess the nonlinear relationship between CMI and kidney stone risk.
CMI levels were positively associated with the prevalence of kidney stones, with the prevalence increasing from 4.33% in the lowest tertile to 9.94% in the highest tertile (P<0.001). Even after adjusting for potential confounders, CMI remained significantly associated with an increased risk of kidney stones (OR = 1.15, 95% CI = 1.10-1.20, P<0.001). Stratified analyses showed that the effect of CMI on kidney stone risk was more pronounced in individuals aged ≥60 years (OR = 1.19, 95% CI = 1.08-1.32, P<0.001) and in males (OR = 1.16, 95% CI = 1.10-1.21, P<0.001), while no significant association was found in females (OR = 1.11, 95% CI = 0.96-1.28, P = 0.157). A nonlinear relationship was observed between CMI and kidney stone risk. Risk significantly increased when CMI was <0.73 (OR = 1.15, 95% CI = 1.10-1.20, P<0.001), while the risk plateaued for CMI ≥0.73 (OR = 1.09, 95% CI = 1.03-1.15, P = 0.002).
Elevated CMI is significantly associated with a higher risk of kidney stones, demonstrating a nonlinear threshold effect. As a comprehensive marker reflecting metabolic burden, CMI may be useful for screening and targeting interventions in high-risk populations for kidney stones.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |