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To explore the causal relationship between obstructive sleep apnea and atherosclerosis which is not clear through Mendelian randomization.
Genome-wide associations of different subtypes of obstructive sleep apnea and atherosclerosis were selected from the data published on the IEU Open GWAS (https://gwas.mrcieu.ac.uk/) website. Inverse variance weighting method (IVW), MR-Egger regression, simple model, weighted model and weighted median method were used to determine the causal correlation between them. A variety of sensitivity analysis and calculating F values were used to verify the accuracy of the results.
Five single nucleotide polymorphisms (Single nucleotide polymorphism, SNP) strongly associated with obstructive sleep apnea were included in the study, and the F values were all greater than 10. The results of IVW method showed that coronary atherosclerosis (OR:1.321,95%CI:1.150-1.518,P=8.3×10-5) had significant statistical significance, while cerebral atherosclerosis(OR:0.331,95%CI:0.071-1.536,P=0.158) and peripheral atherosclerosis (OR:1.204,95%CI:0.962-1.508,P=0.106) had no statistical significance. The results of heterogeneity test, horizontal multiplicity analysis, sensitivity analysis and MR-PRESSO analysis made the causal relationship of Mendelian randomized analysis more reliable.
There is a causal correlation between obstructive sleep apnea and coronary atherosclerosis, and there is a positive correlation between obstructive sleep apnea and coronary atherosclerosis; there is no causal relationship between obstructive sleep apnea and cerebral atherosclerosis and peripheral atherosclerosis; reverse MR analysis found no causal correlation between selected atherosclerosis and obstructive sleep apnea.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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