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To investigate the association between biological aging and cognitive function in middle-aged and elderly Chinese.
The subjects were health check-up personnel over 45 years old from a top three hospital. The general demographic characteristics, covariates and cognitive function status were collected by questionnaire and Montreal cognitive assessment (MoCA). Multivariate linear regression and logistic regression were used to analyze biological aging index (BAI) and biological aging type (BAT) association with MoCA score and risk of mild cognitive impairment (MCI). Subgroup analysis was conducted by the middle-aged group (45-64 years old) and the elderly group (65 years old and above) to explore whether the correlation between biological aging and cognitive function was different in different age groups.
A total of 407 participants were included in this study. The average MoCA score was 23.30±4.30, and the detection rate of MCI was 41.5%. BAI was negatively correlated with MoCA score, and the regression coefficient after adjusting for covariates was -0.135 (95%CI: -0.229--0.042). Compared with those with delayed aging, subjects with premature aging had lower cognitive function scores (β=-0.882，95%CI：-1.566--0.198) and a higher risk of MCI (OR=1.736，95%CI：1.072-2.833). Subgroup analysis found that the association was still present in the middle-aged group, but not in the elderly group.
There is a negative correlation between biological aging and cognitive function in middle-aged and elderly people, and the cognitive function of subjects with premature aging is worse. This effect is more significant in middle-aged group, suggesting that individuals with premature aging should be identified in middle age or even earlier and that intervention measures should be taken to prevent or delay the occurrence of dementia.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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