PDF
Full
Outline
To analyze the correlation between the Geriatric Nutritional Risk Index (GNRI) and the risk of all-cause and cardiovascular disease (CVD) mortality in elderly populations, and to investigate whether the Cardiovascular-Kidney-Metabolic Syndrome (CKM) modulates this association.
This study was based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) cohort data from 2014 to 2018. The baseline was set in 2014, and participants were prospectively followed for 4 years until the follow-up ended in 2018. Participants were divided into two groups according to the Geriatric Nutritional Risk Index (GNRI): the nutritionally normal group (GNRI ≥ 98) and the malnutrition group (GNRI < 98). Kaplan-Meier analysis and log-rank tests were used to assess differences in survival rates between the groups. Restricted cubic spline (RCS) analysis was employed to explore the non-linear relationship between GNRI and survival risk. Cox proportional hazards models were used to evaluate the associations of GNRI and CKM stratifications with survival risk and to investigate the interaction effect of CKM staging.
A total of 1 725 elderly participants were included, and during the 4-year follow-up, 530 cases of all-cause mortality and 160 cases of CVD mortality were recorded. Significant differences in survival probabilities of all-cause and CVD mortality were observed among different GNRI groups (both P<0.001). GNRI showed a linear negative correlation with both all-cause and CVD mortality risks (P<0.001, P for non-linearity>0.05). After adjusting for confounding factors, compared to the nutritionally normal group, the elderly in the poor nutrition group had a 63% higher risk of all-cause mortality (HR=1.63, 95%CI: 1.34 - 1.97) and a 45% higher risk of CVD mortality (HR=1.45, 95%CI: 1.01 - 2.07). Additionally, CKM staging had a significant modulating effect on the association between GNRI and all-cause mortality risk (P for interaction < 0.05), but it did not have a significant modulating effect on the association between GNRI and CVD mortality risk (P for interaction > 0.05).
GNRI is an independent predictor of all-cause and CVD mortality risk in elderly populations, and its protective effect against all-cause mortality risk is more pronounced in patients with earlier CKM staging.
PDF
54
23
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
