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To construct the trajectories of four kinds of scores in Rey Auditory Verbal Learning Test (RAVLT) and to explore the relationship between each trajectory and the progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD).
Data were collected from the Alzheimer’s Disease Neuroimaging Program (ADNI). The research subjects were MCI patients who had been followed up for more than 5 years and completed the RAVLT test. Four kinds of trajectories with different scores of RAVLT were constructed based on the group-based trajectory model (GBTM). Cox regression model was used to explore the relationship between four different score trajectories and the progression of MCI patients to AD.
In the analysis of the four types of RAVLT scores, it was found that three trajectories were identified in the verbal learning scores.Compared with the low-stable group, the risk of AD in the moderate-stable group was lower (adjusted HR=0.27, 95%CI: 0.11-0.71). The delayed recall score identified three trajectories. Compared with the low-stable group, the high-rising group had an increased risk of AD (adjusted HR=3.38, 95%CI: 1.41-8.11).
MCI patients with lower verbal learning scores or higher delayed recall scores have a higher risk of developing AD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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