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Evaluation of the effect of EV71 Vaccine on reported incidence of hand, foot, and mouth disease in Quzhou city based on interruption time series
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Wen-jie XU1, Zhi-ying YIN1, Can-jie ZHENG1, Can-ya FU2, Xiao-ying GONG1, Quan-jun FANG1
Modern Preventive Medicine | 2024, 51(9) : 1702 - 1707
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Modern Preventive Medicine | 2024, 51(9): 1702-1707
• Disease Control and Prevention •
Evaluation of the effect of EV71 Vaccine on reported incidence of hand, foot, and mouth disease in Quzhou city based on interruption time series
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Wen-jie XU1, Zhi-ying YIN1, Can-jie ZHENG1, Can-ya FU2, Xiao-ying GONG1, Quan-jun FANG1
Affiliations
  • Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang 324000, China
Published: 2024-05-10 doi: 10.20043/j.cnki.MPM.202312009
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Objective

To evaluate the effect of EV71 inactivated vaccine on the epidemiological characteristics and reported incidence of hand, foot, and mouth disease (HFMD) in Quzhou city.

Methods

The surveillance data of HFMD cases in Quzhou city from 2009 to 2022 were collected by China Infectious Disease Reporting Information Management system, and the epidemiological characteristics were descriptively analyzed. The change trend of reported incidence of HFMD in Quzhou before and after the application of EV71 inactivated vaccine was analyzed by interruption time series design.

Results

The average reported incidence of HFMD in Quzhou from 2009 to 2022 was 200.02/100 000. After the application of EV71 inactivated vaccine in Quzhou, the instantaneous change of HFMD reported incidence was -30.296/100 000 (t=0.30, P=0.773), the slope changes was-75.694/100 000 (t=5.43, P < 0.001), and the slope was -33.923 (β1+β3=33.923). The proportion of reported cases aged 0 to 4 years in all age groups decreased from 97.72% in 2009—2015 to 90.93% in 2016—2022.

Conclusion

The EV71 vaccine has achieved good prevention and control effect in a short time after coming into the market in Quzhou city, but the incidence rate is still high. It is necessary to strengthen the vaccination of children of school age, especially those less than 12 months old.

Hand, foot, and mouth disease  /  Epidemic characteristics  /  EV71 inactivated vaccine  /  Interruption time series
Wen-jie XU, Zhi-ying YIN, Can-jie ZHENG, Can-ya FU, Xiao-ying GONG, Quan-jun FANG. Evaluation of the effect of EV71 Vaccine on reported incidence of hand, foot, and mouth disease in Quzhou city based on interruption time series[J]. Modern Preventive Medicine, 2024 , 51 (9) : 1702 -1707 . DOI: 10.20043/j.cnki.MPM.202312009
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doi: 10.20043/j.cnki.MPM.202312009
  • Receive Date：2023-12-01
  • Online Date：2026-03-18
  • Published：2024-05-10
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  • Received：2023-12-01
Affiliations
    Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang 324000, China
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栓菌属 Trametes 5 2.39
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