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To systematically analyze the incidence of nutritional risk in patients with Alzheimer’s disease.
Chinese database (WIP, National Knowledge Infrastructure, Wan fang database, Sino Med) and English database (Cochrane library, PubMed, Embase, Web of Science) were searched, and the related studies on the influencing factors of malnutrition in patients with Alzheimer’s disease were collected. After screening and evaluating the literatures according to the criteria, Stata16.0 and Revman5.4 were used to analyze the prevalence of nutritional risk of Alzheimer’s disease and its influencing factors by meta-analysis.
A total of 25 articles were included, the number of patients with Alzheimer’s disease was 3 372, and the number of patients with nutritional risk was 2 038, involving 12 influencing factors. Meta-analysis showed that the prevalence rate of nutritional risk of AD was 62.5% (95%CI: 56.1%-68.9%). Marital status (OR=0.5, 95%CI: 0.34-0.73), course of disease (MD=0.36, 95%CI: 0.05-0.66) and swallowing function (OR=4.86, 95%CI: 1.74-13.61) were the influencing factors of nutritional risk of AD. Albumin (MD=-7.50, 95%CI: -9.25 to -5.75), cholesterol (MD=-0.87, 95%CI: -1.31 to -0.43), and hemoglobin (MD=-2.71, 95%CI: -3.96 to -1.46) were negatively correlated with nutritional risk in Chinese patients with Alzheimer’s disease.
The prevalence rate of nutritional risk in Chinese patients with Alzheimer’s disease is high and is related to marital status, course of disease, albumin, cholesterol, hemoglobin and swallowing function. Clinical attention should be paid to related factors and early identification and intervention to reduce the occurrence of nutritional risk and the impact of nutritional risk on the progression of Alzheimer’s disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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