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Study on the causal relationship between lipoprotein (a) and cerebrovascular disease by two-sample Mendelian randomization analysis
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Xue-qing LIU1, 2, Xiu-qun GONG1, 2, Yu-wen GANG2, Xin-yi XIANG2, Han-xiao LI2, Jun LU2
Modern Preventive Medicine | 2024, 51(9) : 1562 - 1567
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Modern Preventive Medicine | 2024, 51(9): 1562-1567
• Epidemiology and Statistical Methods •
Study on the causal relationship between lipoprotein (a) and cerebrovascular disease by two-sample Mendelian randomization analysis
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Xue-qing LIU1, 2, Xiu-qun GONG1, 2, Yu-wen GANG2, Xin-yi XIANG2, Han-xiao LI2, Jun LU2
Affiliations
  • Department of Neurology, the First Affiliated Hospital of Anhui University of Technology, Huainan, Anhui 232001, China
Published: 2024-05-10 doi: 10.20043/j.cnki.MPM.202311131
Outline
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Objective

To explore the causal relationship between lipoprotein (a) [Lp (a)] and cerebral small vascular disease (CSVD) by Mendelian randomization (MR) analysis.

Methods

Using genome-wide association study (GWAS) public database, the single nucleotide polymorphisms independently associated with Lp (a) (P < 5 × 10-8) were selected as instrumental variables (IVs). The main outcomes of this study were white matter hyperintensity (WMH), cerebral microhemorrhage, and lacunar infarction. Inverse variance weighted (IVW) mothod was used to evaluate the causal relationship between Lp (a) and CSVD. Sensitivity analysis was carried out by MR-Egger and MR-PRESSO to evaluate the pleiotropy of IVs. Furthermore, weighted median method, simple median method, and maximum likelihood ratio method were used to test the reliability of the results.

Results

IVW results showed that there was a positive risk relationship between Lp (a) and WMH (OR=1.083, 95%CI: 1.035-1.134, P <0.001), but Lp (a) was not correlated with cerebral microhemorrhage (P=0.568) and lacunar infarction (P=0.651). MR-Egger analysis showed that the MR analysis of Lp (a) and WMH was not affected by horizontal pleiotropy (P=0.721).

Conclusion

MR analysis shows that Lp (a) is related to the increased risk of WMH.

White matter hypersignal  /  Lipoprotein (a)  /  Mendelian randomization  /  Instrumental variable  /  Causality
Xue-qing LIU, Xiu-qun GONG, Yu-wen GANG, Xin-yi XIANG, Han-xiao LI, Jun LU. Study on the causal relationship between lipoprotein (a) and cerebrovascular disease by two-sample Mendelian randomization analysis[J]. Modern Preventive Medicine, 2024 , 51 (9) : 1562 -1567 . DOI: 10.20043/j.cnki.MPM.202311131
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Year 2024 volume 51 Issue 9
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Article Info
doi: 10.20043/j.cnki.MPM.202311131
  • Receive Date：2023-11-10
  • Online Date：2026-03-18
  • Published：2024-05-10
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  • Received：2023-11-10
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Affiliations
    Department of Neurology, the First Affiliated Hospital of Anhui University of Technology, Huainan, Anhui 232001, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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