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To investigate the relationship between folic acid supplementation behavior and the risk of gestational diabetes mellitus (GDM) in peri-pregnant women, so as to provide evidence for health care of perinatal women.
Based on the monitoring data of pregnancy health care system in Tongzhou district of Beijing from January 2016 to December 2021, multivariate stepwise Logistic regression model and interaction model were used to investigate the effect of folic acid supplementation behavior on the risk of GDM in perinatal women.
A total of 92 708 subjects were included in this study, including 9 926 patients with GDM, with a prevalence rate of 10.71%. The results of Logistic regression analysis showed that folic acid supplementation during perinatal period (OR=0.627, 95%CI: 0.421-0.933), regular folic acid supplementation (OR=0.927,95%CI: 0.887-0.968), simple folic acid supplementation (OR=0.815, 95%CI: 0.778-0.853), and folic acid supplementation before pregnancy (OR=0.921, 95%CI: 0.882-0.963) were associated with the reduced risk of GDM (P<0.05). The results of interaction analysis showed that there was significant interaction between folic acid supplementation type (OR=0.761, 95%CI:0.726-0.798) and folic acid supplementation time (OR=0.721, 95%CI: 0.658-0.791) and whether folic acid supplementation was regular or not (P<0.05).
Folic acid supplementation before pregnancy and folic acid alone can effectively reduce the incidence of GDM. Nutrition and health education before pregnancy should be strengthened and the importance of regular folic acid supplementation before pregnancy should be emphasized in order to reduce the risk of GDM and protect maternal and infant health.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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