Home Journals Articles Updates About
CN
image
收藏切换
A two-sample Mendelian randomized study on the relationship between intestinal microorganisms and anxiety
收藏切换
PDF
Jin-jie FU1, 2, Yuan QIN3, 4, Ling-yong XIAO3, 4, Xiao-yu DAI3, 4
Modern Preventive Medicine | 2024, 51(9) : 1537 - 1543
Less
收藏切换
Modern Preventive Medicine | 2024, 51(9): 1537-1543
• Epidemiology and Statistical Methods •
A two-sample Mendelian randomized study on the relationship between intestinal microorganisms and anxiety
Full
Jin-jie FU1, 2, Yuan QIN3, 4, Ling-yong XIAO3, 4, Xiao-yu DAI3, 4
Affiliations
  • Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Published: 2024-05-10 doi: 10.20043/j.cnki.MPM.202312158
Outline
收藏切换
Objective

To investigate the causal relationship between 211 intestinal microorganisms and anxiety by Mendelian randomization analysis.

Methods

Based on the genome-wide association study data of MiBioGen Alliance and Finnish database, the qualified instrumental variables were extracted, and the inverse variance weighting method was used as the main Mendelian randomized analysis method, combined with MR-Egger and Weighted median methods. Finally, the results were verified by Cochran’s Q statistics, intercept terms of MR-Egger regression, MR-PRESSO, and leave-one-out methods.

Results

Cyanobacteria (OR=1.103, 95%CI: 1.001-1.215, P=0.048), Shigella (OR=1.159, 95%CI: 1.027-1.309, P=0.017), and Slackia (OR=1.170, 95%CI: 1.047-1.307, P=0.017) were positively correlated with the risk of anxiety. Firmicutes (OR=0.857, 95%CI:0.754-0.974, P=0.018), Clostridium (OR=0.817, 95%CI: 0.701-0.951, P=0.009), Clostridium (OR=0.849, 95%CI: 0.736-0.980, P=0.025), Eubacterium_rectale_group (OR=0.861, 95%CI: 0.748-0.993, P=0.039), Ruminococcaceae_UCG004(OR=0.886, 95%CI: 0.789-0.994, P=0.039), and Ruminococcaceae_UCG011(OR=0.919, 95%CI: 0.854-0.989, P=0.025) were negatively correlated with anxiety risk. The results were verified and no heterogeneity and horizontal pleiotropy were found.

Conclusion

This study evaluates the potential causal relationship between intestinal microorganisms and anxiety, providing reference for the diagnosis, prevention and treatment of anxiety in the future.

Anxiety  /  Intestinal microorganisms  /  Causal correlation  /  Mendelian randomization
Jin-jie FU, Yuan QIN, Ling-yong XIAO, Xiao-yu DAI. A two-sample Mendelian randomized study on the relationship between intestinal microorganisms and anxiety[J]. Modern Preventive Medicine, 2024 , 51 (9) : 1537 -1543 . DOI: 10.20043/j.cnki.MPM.202312158
Appendix
Less
Year 2024 volume 51 Issue 9
PDF
51
22
Cite this Article
BibTeX
Article Info
doi: 10.20043/j.cnki.MPM.202312158
  • Receive Date：2023-12-12
  • Online Date：2026-03-18
  • Published：2024-05-10
Article Data
Affiliations
History
  • Received：2023-12-12
Funding
Affiliations
    Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
References
Share
https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202312158
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House