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A Mendelian randomized study on the causal relationship between blood metabolites and heart failure
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Ze-ying* LI1, Tong XU1, Shan JIN1, Cheng-yan WANG1, Li-juan PANG1, 2
Modern Preventive Medicine | 2024, 51(7) : 1320 - 1324
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Modern Preventive Medicine | 2024, 51(7): 1320-1324
• Clinical Medicine and Prevention •
A Mendelian randomized study on the causal relationship between blood metabolites and heart failure
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Ze-ying* LI1, Tong XU1, Shan JIN1, Cheng-yan WANG1, Li-juan PANG1, 2
Affiliations
  • NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital,School of Medicine, Shihezi University)/Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang 832099, China
Published: 2024-04-10 doi: 10.20043/j.cnki.MPM.202311513
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Objective

To evaluate the potential causal relationship between blood metabolites and the risk of heart failure by two-sample Mendelian randomization.

Methods

Based on a genome-wide association study containing 486 blood metabolites, single nucleotide polymorphisms (SNPs) independently associated with blood metabolites was selected as instrumental variables. The heart failure data were derived from the Genome-Wide Association Study of the Molecular Epidemiology Research Consortium for Therapeutic Targets in Heart Failure. The potential causal relationship between them was analyzed by inverse variance weighting method, MR-Egger regression method, and weighted median method, and the sensitivity analysis was perfomed using MR-Egger regression intercept, Cochran Q test, MR-PRESSO, and leave-one-out method.

Results

In total 7 516 SNP associated with blood metabolites were selected as instrumental variables. The results of inverse variance weighting analysis showed that pantothenic acid was associated with heart failure (OR=1.29, 95%CI: 1.03-1.63). Sensitivity analysis results indicated that the results were robust.

Conclusion

This study suggests that there is a positive causal relationship between pantothenic acid and the risk of heart failure, which may provide new insights into the pathogenesis and drug targets of heart failure.

Blood metabolites  /  Heart failure  /  Mendelian randomization  /  Causal inference  /  Pantothenic acid
Ze-ying* LI, Tong XU, Shan JIN, Cheng-yan WANG, Li-juan PANG. A Mendelian randomized study on the causal relationship between blood metabolites and heart failure[J]. Modern Preventive Medicine, 2024 , 51 (7) : 1320 -1324 . DOI: 10.20043/j.cnki.MPM.202311513
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Article Info
doi: 10.20043/j.cnki.MPM.202311513
  • Receive Date：2023-11-27
  • Online Date：2026-03-18
  • Published：2024-04-10
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  • Received：2023-11-27
Funding
Affiliations
    NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital,School of Medicine, Shihezi University)/Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang 832099, China
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https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202311513
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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