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To investigate the relationship between the intake of vegetables and fruits and the composition and diversity ofgut microbiota during the first trimester of pregnancy in Chengdu.
In total 104 early pregnant women in Chengdu were enrolled in this study. Dietary frequency questionnaire was used to collect the intake of vegetables and fruits. According to the median intake of vegetables and fruits, the early pregnant women were divided into high intake group and low intake group. The intestinal microflora of fecal samples of early pregnant women was detected by 16S rRNA highthroughput sequencing, and the differences of intestinal microflora between groups were compared. Multiple linear regression was used to explore the relationship between vegetable and fruit intake and intestinal flora in early pregnant women.
The median intake of vegetables and fruits in early pregnant women was 90.0 g/d and 200.0 g/d, respectively. There was no significant difference in intestinal microflora α and β diversity between high and low intake of vegetables and fruits in early pregnancy. LEfSe analysis showed that the relative abundance of multiple intestinal microflorae in early pregnant women was significantly different between the groups with high and low intake of vegetables and fruits. Multiple linear regression analysis showed that after adjusting age, pre-pregnancy body mass index, and energy intake, early pregnant women’s vegetable intake was directly proportional to the relative abundance of Eubacterium siraeum group (β=0.007, P=0.012), inversely proportional to the relative abundance of Bacteroides (β=-0.167, P=0.023), and fruit intake was proportional to the relative abundance of Ruminococcus gnavus group (β=0.004, P=0.034), inversely proportional to the relative abundance of Agathobacter (β=0.004, P=0.044).
The intake of vegetables and fruits in early pregnancy leads to the change of relative abundance of intestinal flora. This study provides a new scientific basis for dietary regulation of gut microbiota during pregnancy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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