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To explore the causal relationship between lifestyle, diet, sleep, socioeconomic status and bronchial asthma by using two-sample Mendelian randomized method.
Two-sample Mendelian randomization analysis was performed based on inverse variance weighting method (IVW), and the stability and reliability of the results were verified by leaving-one-out method, heterogeneity test, and pleiotropy test.
The results of IVW model showed that smoking (OR=1.17,95%CI: 1.08-1.28), drinking (OR=1.22, 95%CI: 1.05-1.41), sedentary behavior (OR=1.78, 95%CI: 1.38-2.31), sleep duration (OR=2.29, 95%CI: 1.38-2.31), and body mass index (OR=1.41, 95%CI: 1.29-1.53) were associated with the increased risk of bronchial asthma. Fresh fruit intake (OR=0.50, 95%CI: 0.34-0.73), dried fruit intake (OR=0.54, 95%CI: 0.34-0.73), cereal intake (OR=0.62, 95%CI: 0.41-0.94), education level (OR=0.57, 95%CI: 0.34-0.73), and social activity (OR=0.26, 95%CI:0.34-0.73) were associated with reduced risk of asthma. The results of MR-Egger intercept detection did not show pleiotropic effects, indicating that Mendelian randomization was an effective method for causal inference in this study. The heterogeneity test results of drinking (Q=139.92, P=0.001), sedentary behavior (Q=151.37, P=0.003), dried fruit intake (Q=40.00, P=0.007), cereal intake (Q=72.95, P=0.001), and body mass index (BMI) (Q=584.12, P < 0.001) were all statistically significant. Therefore, attention was paid to results of the random effect IVW model.
Smoking, drinking, sedentary behavior, sleep duration, and body mass index may be the risk factors of bronchial asthma. Fresh fruit intake, dried fruit intake, cereal intake, education level, and social activities may be the protective factors of bronchial asthma.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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