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Causal relationship between gut microbiota and insomnia: a two-sample Mendelian randomized analysis
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Ya-dan ZHENG1, Lei LI1, Yang LI1, Cui-hong XIA1, Mao-mao HUANG1, 2, 3, Yue HU1, 2, 3, Dan LI1, 2, 3, Zhang-yu XU1, 2, 3, Fang-yuan XU1, 2, 3, Jian-xiong WANG1, 2, 3
Modern Preventive Medicine | 2024, 51(7) : 1153 - 1160
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Modern Preventive Medicine | 2024, 51(7): 1153-1160
• Epidemiology and Statistical Methods •
Causal relationship between gut microbiota and insomnia: a two-sample Mendelian randomized analysis
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Ya-dan ZHENG1, Lei LI1, Yang LI1, Cui-hong XIA1, Mao-mao HUANG1, 2, 3, Yue HU1, 2, 3, Dan LI1, 2, 3, Zhang-yu XU1, 2, 3, Fang-yuan XU1, 2, 3, Jian-xiong WANG1, 2, 3
Affiliations
  • Department of Rehabilitation Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
Published: 2024-04-10 doi: 10.20043/j.cnki.MPM.202311112
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Objective

To investigate the causal relationship between gut microbiota and insomnia by two-sample Mendelian randomization analysis.

Methods

The summary statistics of gut microbiota came from a meta-analysis of the largest genomewide association study conducted by the MiBioGen Alliance. The summary statistics for insomnia came from the genomewide association study of insomnia measurement. Inverse variance weighted, MR-Egger, weighted median, simple mode method, and weighted mode method were used to study the causal relationship between gut microbiota and insomnia. The stability of the results was evaluated by a series of sensitivity analyses.

Results

MR analysis showed that soft membrane Mollicutes RF9 [β=-0.86, OR(95%CI): 0.42(0.25-0.71)] and unknown family [β=-0.86, OR(95%CI): 0.42(0.25-0.71)] had protective effect on insomnia. In addition, 14 other groups were found to be potentially causally associated with insomnia in this study including Oxalobacteraceae (F=170.153, P=0.034), Marvinbryantia (F=162.702, P=0.006), Ruminococcaceae UCG002 (F=298.323, P=0.046), Subdoligranulum (F=198.442, P=0.045), Anaerostipes (F=222.074, P=0.032), Gammaproteobacteria (F=91.816, P= 0.006) , Pasteurellales (F=231.141, P=0.010), Lachnospiraceae UCG010 (F=138.761, P=0.045), Peptococcus (F=287.210, P=0.036), Ruminococcus gnavus group (F=162.913, P=0.031), Dorea (F=112.086, P=0.049), Flavonifractor (F=95.307, P=0.020), and unknown genus(F=89.189, P=0.001). No significant heterogeneity or pleiotropy was detected.

Conclusion

Mendelian randomization shows that the flexurales, unknown families, and 14 other taxa are causally related to insomnia. The gut microbiota may be one of the treatments to improve insomnia.

Gut microbiota  /  Insomnia  /  Mendelian randomization
Ya-dan ZHENG, Lei LI, Yang LI, Cui-hong XIA, Mao-mao HUANG, Yue HU, Dan LI, Zhang-yu XU, Fang-yuan XU, Jian-xiong WANG. Causal relationship between gut microbiota and insomnia: a two-sample Mendelian randomized analysis[J]. Modern Preventive Medicine, 2024 , 51 (7) : 1153 -1160 . DOI: 10.20043/j.cnki.MPM.202311112
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Year 2024 volume 51 Issue 7
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Article Info
doi: 10.20043/j.cnki.MPM.202311112
  • Receive Date：2023-11-10
  • Online Date：2026-03-18
  • Published：2024-04-10
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  • Received：2023-11-10
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    Department of Rehabilitation Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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