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Objective To investigate whether the amino acid variation in the nonstructural protein of Severe Acute Respiratory Syndrome Coronavirus2 (SARS-CoV-2) is related to the severity of Corona Virus Disease 2019 (COVID-19). Methods The data obtained from the Global Shared Influenza Data Initiative (GISAID) database were analyzed, and the nonstructural protein amino acid mutations with high mutation rate in SARS-CoV-2 sequences were screened. The outcomes were divided into mild and severe diseases, and the chi-square test was used to compare the basic characteristics between the groups. The relationship between the mutations selected and the prognosis of the patients was analyzed. Results A total of 23 498 cases were included, including 11 444 males (48.70%) and 12 054 females (51.30%). The median age ［M（P25，P75）］ was 38 (26-53) years old. The severe infection rate of novel coronavirus in male was higher than that in female (χ2=226.564, P < 0.001). The severe infection rate of novel coronavirus increased with the increase of age (χ2=6 088.032, P < 0.001). The year of onset (χ2=1 604.070, P <0.001) and continent (χ2=4 520.240, P < 0.001) were significantly correlated with the severity of novel corona virus infection.Several amino acid variations in the SARS-CoV-2 gene group associated with the severity of novel corona virus’s sensitive dyeing were determined. NSP4_T492I (aOR=0.574, 95%CI: 0.487-0.676), NSP12_G671S (aOR=0.657, 95%CI: 0.458-0.941),NSP6_T77A (aOR=0.422, 95%CI: 0.235-0.759), and NSP3_P1228L (aOR=0.124, 95%CI: 0.080-0.190) were negatively correlated with novel coronavirus’s severe infection. NSP12_P323L (aOR=2.126, 95%CI: 1.531-2.953), NSP13_P77L (aOR=1.923, 95%CI: 1.115-2.369), and NSP14_A394V (aOR=20.486, 95%CI: 9.649-43.495) were positively correlated with novel coronavirus’s severe infection. Conclusion The amino acid variation of SARS-CoV-2 nonstructural protein may be related to the severity of COVID-19 virus infection, and it is necessary to screen several nonstructural protein amino acid variants which can be related to the severity of novel coronavirus infection.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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