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To explore the potential relationship between dietary carotenoid intake and neurodegenerative diseases based on NHANES data.
A multifactorial logistic regression model was used to analyze the relationship between dietary carotenoid intake and neurodegenerative diseases and to explore the association between dietary carotenoid intake and neurodegenerative diseases in different gender and age subgroups, using the NHANES database of people aged 40 years and older from 2003-2018 as the study population.
Of the 23 108 study participants included in this study, 216 had Parkinson’s disease dementia (PD) and 183 had Alzheimer’s disease (AD). The carotenoid intake of PD patients (7,597.9 mcg/d) was significantly lower than that of the normal population (8,719.8 mcg/d) and the difference was statistically significant, while that of AD patients (7 189.8 mcg/d) was significantly lower than that of the normal population (8,721.4 mcg/d) and the difference was statistically significant. After adjusting for age, sex, body mass index, race, education, alcohol consumption, smoking, household poverty-to-income ratio, hypertension, diabetes mellitus, Cardiovascular disease and the NHANES cycle, the prevalence of PD was significantly lower in the highest tertile group compared with the lowest tertile group (OR=0.65, 95% CI: 0.44-0.98), and the risk of AD was significantly lower in the Q2 group (OR=0.65, 95% CI: 0.43-0.99). In subgroup analyses, a lower risk of PD was observed in the group with the highest dietary carotenoid intake in those aged 70 years or older (OR=0.52, 95% CI: 0.30-0.96); the protective effect of dietary carotenoid intake on AD was demonstrated in the Q4 group of women (OR=0.49, 95% CI: 0.26-0.93).
There is a negative association between carotenoid intake and the risk of developing neurodegenerative diseases, and carotenoids may be a protective factor against neurodegenerative diseases, a relationship that varies by age, sex, and whether or not the individual has hypertension or diabetes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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