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Mechanistic study of curcumin in the tertiary prevention strategy of non-small cell lung cancer
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Luo-jie LI1, Shi-chang YAN1, Qiu-xia YE2, Chuan MA3, Yuan-qiong HE1, Si-ru CHEN1, Hua XIAO1
Modern Preventive Medicine | 2025, 52(8) : 1517 - 1524
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Modern Preventive Medicine | 2025, 52(8): 1517-1524
Clinical Medicine and Prevention
Mechanistic study of curcumin in the tertiary prevention strategy of non-small cell lung cancer
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Luo-jie LI1, Shi-chang YAN1, Qiu-xia YE2, Chuan MA3, Yuan-qiong HE1, Si-ru CHEN1, Hua XIAO1
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  • College of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, China
Published: 2025-04-25 doi: 10.20043/j.cnki.MPM.202501139
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Non-small cell lung cancer is a common malignant tumor with soaring incidence and mortality rates. Although various existing treatment methods have extended the survival period of patients, the prognosis remains poor. Therefore, standardizing the Tertiary prevention strategy for lung cancer is extremely crucial. The Tertiary prevention strategy for lung cancer is divided into: primary cause prevention, secondary early prevention, and tertiary clinical prevention. Curcumin has become a hotspot in lung cancer prevention due to its broad biological activity and low toxicity. Derived from turmeric, it possesses various pharmacological activities, capable of inhibiting lung cancer cell proliferation, inducing apoptosis, and resisting invasion and metastasis, showing significant anti-tumor potential, and has application potential in the Tertiary prevention of lung cancer. This article reviews the latest achievements of curcumin and its combination with chemotherapy drugs from January 2010 to January 2025 in databases such as PubMed and CNKI, elucidating its multifaceted roles in the Tertiary prevention strategy of lung cancer. However, curcumin faces issues such as rapid metabolism, poor oral bioavailability, and limited water solubility, slightly hindering its clinical application, but it still holds promise as a potential medication or auxiliary means for theTertiary prevention of non-small cell lung cancer.

Curcumin  /  Non-small cell lung cancer  /  Tertiary prevention  /  Mechanisms of action
Luo-jie LI, Shi-chang YAN, Qiu-xia YE, Chuan MA, Yuan-qiong HE, Si-ru CHEN, Hua XIAO. Mechanistic study of curcumin in the tertiary prevention strategy of non-small cell lung cancer[J]. Modern Preventive Medicine, 2025 , 52 (8) : 1517 -1524 . DOI: 10.20043/j.cnki.MPM.202501139
Year 2025 volume 52 Issue 8
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doi: 10.20043/j.cnki.MPM.202501139
  • Receive Date:2025-01-08
  • Online Date:2026-03-17
  • Published:2025-04-25
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  • Received:2025-01-08
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    College of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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